Directly from the paper covered by the post earlier, 90 year old equivalent mouse before and after treatment with FOXO4 D reverso inversio peptide, a FOXO4 inhibitor that blocks FOXO4 from arresting senescent cell apoptosis. FOXO4 DRI 10mg Ion Peptide Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging: Cell A new class of drugs called senolytics works by hunting down and destroying senescent "zombie cells" that accumulate with age and drive wrinkles, weak bones, and organ decline. In an early human
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foxo4-dri senolytic human trial FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation