Why Glutathione Matters for Chemical Sensitivity and MTHFR Variants MTHFR Gene Mutation Symptoms Allergy Research Group Meta Analysis of Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and its association with folate and colorectal cancer BMC Cancer Springer Nature Link The detox gene (MTHFR) is rendered inactive when your diet is high in meat. Our diet should be 80% plant based or higher.