What Caused These Multiple Hyperpigmented Macules of the Mouth? Melanotic macules of the tongue in a newborn Journal of the American Academy of Dermatology Spotty lips. These are labial melanotic macules, kinda like freckles on the lips. They are mostly due to age and sun exposure, but sometimes they run in families and are associated with Peutz Jeghers syndrome: black spots localized in the perioral area. Download Scientific Diagram
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melanotic macule causes Ch22: Pigmentations of the Oral Mucosa and Facial Skin