Quantification of paracetamol and 5 oxoproline in serum by capillary electrophoresis: Implication for clinical toxicology ScienceDirect Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Paracetamol (acetaminophen) toxicity occurs when the liver is overwhelmed by a toxic metabolite called N acetyl p benzoquinone imine (NAPQI), which is normally detoxified by glutathione. In overdose, glutathione is depleted, and NAPQI accumulates, leading Glutathione Amino Acids: Why Supplements May Not Work