Iron Metabolism and Hemochromatosis: Pathogenic Pathways to Multiple Organ Dysfunction Clinical and Therapeutic Implications IntechOpen Iron metabolism and ferroptosis in health and diseases: The crucial role of mitochondria in metabolically active tissues ScienceDirect Iron Overload, Oxidative Stress, and Ferroptosis in the Failing Heart and Liver Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects Signal Transduction and Targeted Therapy