How Mycotoxins Trigger Mast Cell Activation and Brain Inflammation Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis Cell Death & Disease Mast Cell Activation Syndrome San Diego Naturopathic Doctor & IV Therapy