Clinical associations and potential cellular mechanisms linking G6PD deficiency and atherosclerotic cardiovascular disease npj Metabolic Health and Disease Glucose 6 phosphate dehydrogenase (G6PD) deficiency: Video, Causes, & Meaning Osmosis G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No Glucose 6 phosphate dehydrogenase deficiency and risk of cardiovascular disease: A propensity score matched study Atherosclerosis