I've read taking glutathione actually causes your body to stop making it on its own, and instead we should be supporting our body in ways to encourage it to up its own Glutathione Synthetase Deficiency StoryMD Glutathione deficiency induces epigenetic alterations of vitamin D metabolism genes in the livers of high fat diet fed obese mice Scientific Reports Glutamine Synthetase: Diverse Regulation and Functions of an Ancient Enzyme Biochemistry